Xenadrine EFX Clinical Trials and Studies

Xenadrine EFX Information

Xenadrine EFX Clinical Trials and Studies

Citrus aurantium

A study published in Current Therapeutic Research recently investigated the weight-loss benefits of a supplement containing Citrus aurantium, caffeine and St. John's wort. The researchers divided 23 overweight individuals into three groups. One was given the Citrus aurantium combination. Another group got a placebo, while the third group did not receive any supplement. All of the subjects followed the same exercise and diet routine for six weeks. By the end of the experiment, the Citrus aurantium group had lost 13% of their fat mass while increasing their basal metabolic rate by 3%. While the St. John's wort, an herbal antidepressant, may have reduced appetite to some extent (people tend to eat more when they are depressed), the researchers felt that the synephrine/caffeine part of the formulation was the primary reason for the benefits in fat loss and enhanced metabolism. No published studies have examined the benefits of Citrus aurantium on its own, or in the specific Xenadrine EFX formulation.

Caffeine

Scientific research shows that caffeine is not only a powerful thermogenic stimulator, but also works synergistically with ephedrine and synephrine. Studies show that caffeine increases the level of free fatty acids in your blood, thereby making fat a more abundant source of fuel.

One study found a 100% increase in plasma free fatty acids after taking 330 mg of caffeine. Studies also show that during aerobic exercise, caffeine can increase the rate of fat oxidation (fat burning) by as much as 50%. That means that if you spent 30 minutes doing moderately intense aerobic exercise and burned 500 calories, roughly half of those calories would come from fat oxidation. So by adding caffeine to your pre-workout supplement list, you could theoretically burn an extra 125 calories. Add that up over a period of weeks, months or years, and you'll understand why adding caffeine to Xenadrine EFX is important for jump-starting your weight-loss efforts.

However, scientists have discovered a more profound synergistic effect when caffeine is combined with ephedrine. Together, these two nutrients are much more beneficial than the combined effects when each is taken separately. Since synephrine is a chemical cousin to ephedrine, it may have a similar synergistic effect with caffeine. While Xenadrine Rfa 1 uses this combination, Xenadrine EFX does not.

A study in the American Journal of Clinical Nutrition found that when green tea was taken instead of pure caffeine, there was a greater thermogenic effect. This six-week study compared the benefits of pure caffeine (50 mg), green tea extract (with 50 mg of caffeine and 90 mg of EGCG) and placebo. The pills were given three times per day. The green tea group experienced a significant 4% increase in thermogenesis and a 4.5% boost in overall energy expenditure. Green tea is combined with caffeine in Xenadrine EFX.

Cocoa extract contains some caffeine as well as other plant chemicals that act as stimulants, including theobromine. One four-day study with rats found that theobromine administration produced a very favorable reduction in fatty-acid levels in the blood, suggesting that the fat may have been metabolized for energy. Unfortunately, the rats had to consume 700 mg of theobromine per kg of body weight to get this effect. Given that theobromine only makes up about 2% of cocoa by weight, a human would need to eat pounds of chocolate to get this same effect. No studies have yet been published with humans taking more reasonable amounts of theobromine or cocoa extract.

Yerba mate contains caffeine as well as smaller amounts of the stimulants theophylline and theobromine. As such, it should give Xenadrine another effective source of caffeine, provided that enough of the plant extract is consumed. However, to date no research has been published on the efficacy of yerba mate as a fat burner.

L-tyrosine

Research suggests that supplementing with tyrosine may minimize the degradation of the neurotransmitters involved in the metabolic process while enhancing the thermogenic effects of the ECA stack. With more raw material available, the neurotransmitters controlling metabolism are produced at a higher level with beneficial results. The increases in alertness and energy level will also make it easier to stick to your Xenadrine EFX diet program.

Ginger root

Ginger has a long history of use as a treatment for motion sickness. In one double-blind, placebo-controlled study by Danish researchers, naval cadets unaccustomed to sailing in rough seas were given 1 gm of ginger root or placebo every hour for four hours. The ginger root reduced the tendency toward vomiting and cold sweating. Thermogenic formulations such as Xenadrine EFX only produce gastrointestinal distress in some sensitive individuals, so ginger should definitely be able to relieve these much milder symptoms. There are no studies showing that ginger by itself has fat-burning properties.

Di-methionine

Methionine is an amino acid that must be obtained from the diet, as the body cannot manufacture it. It assists in fat breakdown (lipolysis), although it has many other roles in the body. Methionine is included in fat-burner formulations because of its ability to support greater levels of fatty-acid oxidation. However, it has not been studied as a fat burner on its own, so it is not known how much methionine in Xenadrine EFX is needed to promote significant levels of fat loss.

DMAE

DMAE can enhance acetylcholine function in the central nervous system. The end result in more energy and alertness, potentially boosting your willpower as you cut your calories. While DMAE has been shown to increase mental functioning in many disease conditions (including Alzheimer's disease and attention deficit disorder), no one has yet studied its impact on fat loss as a separate supplement.

Grape seed extract

Grape seed extract is a powerful antioxidant with numerous health benefits. However, no published study has shown that it actually has the ability to redirect fatty acids away from the fat cells, as some products claim. Xenadrine pretty much uses it as a way to fight free radicals and keep you healthy.

Xenadrine EFX Information